Targeted molecular discovery begins with the 3D structure of the biomolecular target, which is usually a protein. TTPostGene® accepts as input information about the protein target, either the name of the target or the primary sequence.  If the structure is known, the structure is retrieved from protein structure databases.  Alternately, if the structure is not known, the target protein primary amino acid sequence may be used to retrieve structures of homologous proteins and 3D homology models are constructed.  If there are no homologous protein structures available, threading techniques are used by TTPostGene provides these 3D structures of the biomolecular target. TTPostGene® accepts as input information about the protein target, either the name of the target or the primary sequence.  If the structure is known, the structure is retrieved from protein structure databases.  Alternately, if the structure is not known, the target protein primary amino acid sequence may be used to retrieve structures of homologous proteins and 3D homology models are constructed.  If there are no homologous protein structures available, threading techniques are used by TTPostGene® to generate suitable 3D models from primary sequence of the target protein.  In these scenarios multiple 3D models may be generated and any or all of these may be utilized in the ensuing stages of TTPredict®.