|
TransTech Pharma has the only known AgRP inhibitors in clinical development.
HPP515 is a potent and selective AgRP inhibitor. Our AgRP inhibitors, TTP435 and HPP515, have not shown meaningful changes in blood pressure in any of our clinical or preclinical studies.
TTP515 significantly increases the number of solicitations after acute or sub-chronic administration in ovariectomized female rats and increases the frequency of high Intensity lordosis (mating posture) after acute or sub-chronic administration in ovariectomized female rats.
AgRP inhibitors stimulate the melanocortin system and should work in both pre- and post-menopausal women.
|